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Human Prostate-Specific Antigen Carries N-Glycans with Ketodeoxynononic Acid Article
Wei Wang, Tao Zhang, Jan Nouta, Peter A. van Veelen, Noortje de Haan, Theo M. de Reijke, Manfred Wuhrer, Guinevere S.M. Lageveen-Kammeijer
Engineering 2023, Volume 26, Issue 7, Pages 119-131 doi: 10.1016/j.eng.2023.02.009
Ketodeoxynononic acid (Kdn) is a rather uncommon class of sialic acid in mammals.However, associations have been found between elevated concentrations of free or conjugated Kdn in relationHitherto, there has been a lack of conclusive evidence that Kdn occurs on (specific) human glycoproteins(conjugated Kdn).Here, we report for the first time that Kdn is expressed on prostate-specific antigen (PSA) N
Keywords： Ketodeoxynononic acid Kdn Glycosylation Prostate cancer Prostate-specific antigen
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